BDNF Gene Methylation and the Creatine-Phosphate System: A Translational Perspective for Neuropharmaceutical Innovation
DOI:
https://doi.org/10.6020/85kttp31Keywords:
BDNF, creatine, epigenetics, brain metabolismo, neuropharmacology, biomarker, translational researchAbstract
The maintenance of synaptic function and neuroplasticity relies on an intricate balance of genetic, epigenetic, and metabolic factors. Brain-Derived Neurotrophic Factor (BDNF), a key protein for neuronal health, is regulated by DNA methylation patterns that influence its expression. Concurrently, the creatine-phosphate (PCr) system serves as a critical energy buffer, especially in the brain during high metabolic demand. Here, we present a perspective on the potential interaction between creatine mediated BDNF gene methylation and cerebral bioenergetics. While direct mechanistic data are still lacking, emerging evidence suggests that creatine supplementation may enhance BDNF expression and modulate synaptic energetics. These insights support the hypothesis that creatine-based interven-
tions could be personalized through epigenetic biomarkers, offering novel opportunities for translational research and pharmaceutical innovation in the treatment of neuropsychiatric conditions.
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